Sp3 Sp3 transcription factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Sp3provided by RGD
Full Name: Sp3 transcription factorprovided by RGD
Primary source: RGD:1583765
See related: Ensembl:ENSRNOG00000060479 AllianceGenome:RGD:1583765
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription, DNA-templated. Located in nucleus. Part of protein-DNA complex and transcription repressor complex. Orthologous to human SP3 (Sp3 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 609.8), Spleen (RPKM 392.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q23

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (78219421..78272318, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (57811855..57857150, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (59644579..59689011, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Superoxide activates renal Sp3 via lysine acetylation increasing renin activity, AT1R function, and blood pressure in rats.
Title: Superoxide via Sp3 mechanism increases renal renin activity, renal AT1 receptor function, and blood pressure in rats.
These results suggest that XT-1 expression is refractory to the disease process and to inhibition by inflammatory cytokines and that signaling through AP-1, Sp1, and Sp3 is important in the maintenance of XT-1 levels in NP cells.
Title: Xylosyltransferase-1 expression is refractory to inhibition by the inflammatory cytokines tumor necrosis factor α and IL-1β in nucleus pulposus cells: novel regulation by AP-1, Sp1, and Sp3.
Sp1 and Sp3 transcription factors mediate leptin-induced collagen alpha1(I) gene expression in primary culture of male rat hepatic stellate cells
Title: Sp1 and Sp3 transcription factors mediate leptin-induced collagen α1(I) gene expression in primary culture of male rat hepatic stellate cells.
Results provide new insight into the regulatory mechanisms of Pdgfra transcription in Leydig cells, which includes a role for the transcription factors SP1 and SP3.
Title: Transcription of platelet-derived growth factor receptor α in Leydig cells involves specificity protein 1 and 3.
The role of Sp3 in apoptosis was assessed via gene silencing and glutamine administration.
Title: Glutamine protects against apoptosis via downregulation of Sp3 in intestinal epithelial cells.
Data suggest that Sp1 and Sp3 play a role in the regulation of 5alpha-R gene expression, and hence the production of 5alpha-reduced neurosteroids in glial cells.
Title: Trichostatin A stimulates steroid 5alpha-reductase gene expression in rat C6 glioma cells via a mechanism involving Sp1 and Sp3 transcription factors.
Data indicat that Sp3 was present in the nuclear and cytoplasmic compartments of neonatal cardiomyocytes.
Title: Fibroblast growth factor receptor 1 gene expression is required for cardiomyocyte proliferation and is repressed by Sp3.
Stat1/3 directly controls promoter P1 of the CASR, and the Stats indirectly regulate promoter P2 of the CASR via Sp1/3 in response to IL-6
Title: The proinflammatory cytokine, interleukin-6, up-regulates calcium-sensing receptor gene transcription via Stat1/3 and Sp1/3.
Sp1 and Sp3 are found associated with native proximal promoter of cyclic AMP (cAMP)-dependent GTP cyclohydrolase I in PC12 cells but are not recruited to the promoter during cAMP-dependent transcription.
Title: Specificity proteins Sp1 and Sp3 interact with the rat GTP cyclohydrolase I proximal promoter to regulate transcription.
We conclude that the mechanism of basal control of rat NHE2 gene promoter activity is different in the renal and intestinal epithelium, with Sp3 being the major transcriptional activator of NHE2 gene transcription in the intestinal epithelial cells.
Title: Sp1 and Sp3 mediate NHE2 gene transcription in the intestinal epithelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (20)

General gene information

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Markers

PMC305603P1 (e-PCR)
- UniSTS:272552

RH140061 (e-PCR)
- UniSTS:222142

RH133751 (e-PCR)
- UniSTS:217034

PMC169877P1 (e-PCR)
- UniSTS:271610

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IGI Inferred from Genetic Interaction more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within definitive hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic placenta development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic process involved in female pregnancy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within enucleate erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within granulocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within megakaryocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ossification	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IC Inferred by Curator more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trophectodermal cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	IPI Inferred from Physical Interaction more info	PubMed
part_of transcription repressor complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor Sp3

Names: trans-acting transcription factor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427405.1 → NP_001414334.1 transcription factor Sp3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6A0B6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

78219421..78272318 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063284296.1 → XP_063140366.1 transcription factor Sp3 isoform X1

UniProtKB/TrEMBL

A0A8I6A0B6
XM_063284295.1 → XP_063140365.1 transcription factor Sp3 isoform X1

UniProtKB/TrEMBL

A0A8I6A0B6
XM_063284297.1 → XP_063140367.1 transcription factor Sp3 isoform X1

UniProtKB/TrEMBL

A0A8I6A0B6
XM_039106378.2 → XP_038962306.1 transcription factor Sp3 isoform X2

UniProtKB/TrEMBL

A0A0G2K5M1, A0A8I6AEE9

Related

ENSRNOP00000090911.1

Conserved Domains (4) summary

sd00017
Location:581 → 603

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:639 → 661

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:625 → 648

zf-H2C2_2; Zinc-finger double domain

cd22537
Location:2 → 580

SP3_N; N-terminal domain of transcription factor Specificity Protein (SP) 3
XM_039106379.2 → XP_038962307.1 transcription factor Sp3 isoform X3

UniProtKB/TrEMBL

A6HM81

Conserved Domains (4) summary

sd00017
Location:338 → 360

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:396 → 418

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:382 → 405

zf-H2C2_2; Zinc-finger double domain

cl41773
Location:1 → 337

SP1-4_N; N-terminal domain of transcription factor Specificity Proteins (SP) 1-4

RNA

XR_010064675.1 RNA Sequence
XR_005502231.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001029905.1: Suppressed sequence

Description

NM_001029905.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.